Barnsley to travel to Fratton Park.
The Reds were ball number 17 in the draw, for Round Four of the Emirates FA Cup.
Portsmouth FC vs Barnsley FC
Drawn out as one of the last few ties, Gerhard Struber's side will face Portsmouth at Fratton Park. The last meeting between the two teams in Hampshire was during the Reds' promotion winning 2018/19 campaign, which saw the match end in a 0-0 draw.
The date and ticket details will follow on barnsleyfc.co.uk, once confirmed.