The Reds head to the Kassam Stadium on Tuesday night as the Sky Bet League One fixtures keep on coming, and we've got everything covered in our big match preview.
Following yet another victory at the weekend - the Reds' third on the spin - it's straight back into it with a trip south to Oxford to take on the struggling U's.
Saturday's 2-1 win against a similarly out of form Rochdale saw Daniel Stendel's side move up to 3rd in the table and a win in this game could see his men jump into 2nd.
Second half goals from strikers Kieffer Moore and Cauley Woodrow were enough to turn around the match having been behind early in the second half.
It was just the second time Barnsley had come from behind to win this season, having come back from a goal down to beat Fleetwood Town away 3-1 back in September.
The success over Dale also extended the side's unbeaten league run to eight games and maintained their unbeaten record at Oakwell in the league this season.
In terms of squad selection, Stendel has hinted at perhaps freshening his starting XI up a little, considering the amount of games that are coming thick and fast.
Injury-wise, Mike Bähre is back in training after his brief layoff so he may come into contention whilst Jack Walton is probably 10 days away from full contact training.
The Reds' Head Coach was on press duty ahead of the match and you can watch his full, 20 minute pre-match press conference video over on iFollow Barnsley.
Our hosts on Tuesday night are currently sitting 21st in the league standings, inside the dreaded drop-zone, much to the surprise of many pundits who tipped Karl Robinson's men for much better things this season.
Due to cup competitions, United haven't played a league fixture since January 19th but that game saw them beat the then league leaders, Portsmouth 2-1 on home soil.
Their 30 points accrued thus far sees them just one behind Rochdale and escaping the bottom four.
Influential forward James Henry has been in fine form this season even if his team haven't. The 29-year-old former Millwall man has 10 goals to his name, with nine of them scored from inside the box.
Their squad is packed with experience. The likes of Curtis Nelson, John Mousinho and Jamie Mackie have been around the block and following that superb victory last time out, you would imagine Oxford will be confident of finding some form and moving out of trouble.
Robinson was appointed Head Coach in March of last year, but the man who made his name with MK Dons will have expected to have fared much better since taking the job at the Kassam Stadium.
He left Charlton sitting 9th in the table when taking the U's job, and whilst his current side are struggling, the Addicks are right in the promotion mix with the Reds.
The two sides met on the opening day of the season at Oakwell, with Stendel kicking off his time as Barnsley FC Head Coach with a resounding 4-0 triumph that pretty much set the tone for the campaign.
On a hot summer's day in South Yorkshire, a brace from Mamadou Thiam followed by second half Brad Potts and Victor Adeboyejo goals saw Barnsley start the season in style.
This isn't - historically - a fixture that's often played. with both clubs in different divisions for much of their history, there have been just 24 previous clashes.
The standout fixture being of course the 3-2 Reds victory in April of 2016 when Barnsley saw off the U's to lift the Football League Trophy at Wembley.
When the Reds pitch up at the Kassam Stadium on Tuesday night it will be their first visit to Oxford in 20 years (30th January 1999) and their first visit to this particular ground which opened in 2001.
It was 1979 when the sides first locked horns. United won on that occasion in a Division Three clash by a goal to nil.
However, the Reds edge this fixture with 12 victories to Oxford's seven.
The referee for this one is Mr Kevin Johnson.
The Somerset-based official has only taken charge of one Reds match previously, but that was a League One away win against Gillingham in February 2015.
With this being a midweek game, iFollow Barnsley will be offering Match Passes to both overseas and UK viewers.
Follow the link below to watch the Reds take on the Yellows for just £10!