Barnsley 2 ( O'Brien 76, Done 90+2)
Portsmouth 0 (Kitson s/o 40)
Two great goals earned the Reds all the points in a solid display of grit and determination. An already struggling Pompey side were dealt an even bigger blow just before the break as Kitson's wild challenge on Smith earned the striker his second yellow and subsequent marching orders.
On six minutes Craig Davies showed great patience and technique as he lobbed towards Henderson's goal only to see his 20-yard effort bounce off the top of the crossbar.
It was a steady opening to the game with very few clear-cut chances, although the Reds were putting their opponents under considerable pressure with Pompey happy to counter.
A few half-hearted shouts for a penalty were turned down when Foster was hauled to the ground inside the area as Hill's men pressed.
Portsmouth's response came through Huseklepp as the Norwegian flashed just wide of Steele's left-hand upright following a tasty delivery.
It might all be doom and gloom for the visitors but their loyal support was just as incredible as it always has been - singing their hearts out from the off.
Before the half-hour mark a blow came in central-midfield for the Reds as David Perkins had to be replaced by Jay McEveley following a heavy challenge - with Jimmy McNulty moving into midfield.
If Portsmouth were meant to have a struggle on their hands before kick-off, their task was made even bigger just before half-time as Dave Kitson was given his marching orders. It came as a second booking for the striker who lunged late at Korey Smith.
After Huseklepp fired wide the Reds almost broke the deadlock nine minutes into the second half through an own goal but a header from a Pompey defender drifted just wide with the crowd waiting for the net to bulge.
The match had turned into a real battle, with the visitors taking their time with every piece of play - happy to dig in and try and earn a point with ten men.
It was all Barnsley but Portsmouth were proving to be a tough nut to crack - working hard to block out the Reds. Futacs was isolated up front for Pompey and Steele was happy to gobble up the clearances.
Finally, finally the goal game on 76 minutes with a great finish from Jim O'Brien. Patience is certainly a virtue - and O'Brien reaped the rewards from 20 yards. McNulty teed up the winger who was back in the starting XI and he caught out Henderson with a curling effort in front of the relieved Ponty End.
The goal breathe a new lease of life into the Reds and they went in search of another and they had to wait until stoppage time for it.
When Portsmouth were awarded a harsh free-kick, the Reds cleared and Matty Done showed tremendous pace and determination to break forward and hurdled a lunge to hack him down before keeping his head when through on goal for 2-0. Excellent goal from Barnsley.
One clean sheet, two goals and three points - just what the Doctor ordered.
Barnsley: Steele, Edwards, Foster, O'Brien, Davies, Perkins (McEveley 29), Wiseman, McNulty, Smith, Golbourne (Done 71), Gray (Dagnall 65).
Subs: Preece, Cotterill.
Portsmouth: Henderson, Ward, Rocha (Benjani 85), Mokoena, Pearce, Mullins, Futacs, Huseklepp, Kitson (s/o 42), Thorn, Ben-Haim.
Subs: Ashdown, Webster.
Referee: Eddie Ilderton