Burnley 2 (Rodriguez 4, Austin 63)
Goals in either half sealed a home victory for Burnley, but it could have been so different had Craig Davies' thunderbolt not cracked the crossbar with his side a goal down.
The crowd had barely settled into their seats when Jay Rodriguez notched the opener - and Keith Hill certainly didn't look happy with how it came about. Wallace was given enough time and space to deliver for McQuoid, and although his header seemed to be creeping into the far corner of the net, Jay Rodriguez pounced to make sure on the line.
Howe's men were looking charged up and took control of the match as the Reds sought a way in - and it almost came when Davies half-volleyed towards the near post on 16 minutes but it was half a chance that the strike made the most of.
After Austin flashed a header over from a Trippier delivery, Grant was tested in the 18th minute as Davies once again took aim from long range but could only power straight at the former Wednesday stopper.
Just as the Reds were gaining a foothold in the match, it was Burnley who came closest to score again on 26 minutes with that man Rodriguez striking just wide from 22 yards after a neat lay-off from Charlie Austin.
The hosts' skipper, Chris McCann was then booked for simulation as he looked for a penalty, but the referee was wise to his intentions.
A real blow came just before the half-hour mark when Michael Tonge limped off, but there was a welcome return for Jim O'Brien.
As the clock ticked down on the first half, the Burnley fans were certain their side should have had a second as David Perkins' goal-line clearance denied the hosts another. Charlie Austin climbed highest to greet a wonderful Trippier corner but Perkins was in the right place at the right time.
After a first half to forget, Keith Hill threw all of his eggs in one basket as Nathan Doyle and Chris Dagnall made it all three substitutions used with Done and Perkins being replaced.
It was a great start to the second period as the Reds showed a renewed belief and energy that was missing in the first period. Davies curled a free-kick over before Rodriguez flicked a header just wide at the other end as the game stretched.
It really should have been two as Rodriguez once more connected with Trippier's pinpoint delivery but got underneath the ball and nodded over from eight yards on 52 minutes.
A wonderful break from Barnsley saw Craig Davies absolutely spank the crossbar from 25 yards with a thunderbolt that beat Grant then, agonisingly, Dagnall's effort from the rebound was blocked by his own team-mate Gray. It was a great break from O'Brien initially - the winger back from injury and looking lively.
For all of Barnsley's fight and threat, the match effectively slipped away when the hosts hit the Reds on the counter. Rodriguez was picked out in acres of space on the edge of the box and although his effort hit the post, the rebound kindly fell into the path of Austin and his strike on the rebound certainly didn't hit a team-mate and he tapped into the empty net on 63 minutes.
When a massive gap appeared in the Reds' defence on 75 minutes, Charlie Austin went through on goal but scuffed wide from 12 yards.
Golbourne's great through-ball for O'Brien enabled the winger to deliver for Wiseman but the full-back's strike went well over via a Clarets block as the clock ticked down.
It was obvious the Reds' luck wasn't in as Andy Gray was a matter of inches away from a consolation strike as a deflection took Wiseman's cross away from his head in stoppage time.
It was a shame that a matter of centimetres came between the two sides with Davies' strike onto the crossbar almost hauled his side level, but it just wasn't the Reds' night despite a solid second-half effort.
Burnley: Grant, Edgar, Mee, Duff, Trippier (Easton 92), McQuoid, Marney, McCann, Wallace (Bartley 82), Austin (Ings 82) , Rodriguez
Subs: Jensen, Treacey.
Reds: Steele, Wiseman, Edwards, McNulty, Golbourne, Perkins (Doyle 46), Smith, Done (Dagnall 46), Tonge (O'Brien 29), Davies, Gray.
Subs: Preece, Foster.
Referee: Oliver Langford
Assistant Referees: Gordon Johnson & Matthew Parry
Fourth Official: Jonathan Hunt